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NEW CRP: New Ways of Producing Tc-99m and Tc-99m Generators (F22068)

A view to National Research Council Canada (NRC) LINAC. (Photo: Canadian Crown Copyright)

Technetium-99m (Tc-99m) radiopharmaceuticals are the major diagnostic tools in the clinical practice of nuclear medicine worldwide covering 35 million procedures annually. They play an important role in the diagnosis of cancer patients, cardiac patients and many other conditions. Tc-99m is the decay product of longer-lived Molybdenum-99 (Mo-99) and can be made from a generator system (Mo-99/Tc-99m). The major part of Mo-99 for generator development comes from the fission route which is a well-established method.

Due to the recent crisis in availability of Mo-99, many interesting achievements in the development of new methods of Tc-99m and Mo-99 production have taken place. This Coordinated Research Project (CRP) will identify new technical aspects of the production and quality control of Mo-99 and Tc-99m and T-99m generators focusing on the photodynamic route through the reaction Mo-100(g,n)Mo-99, as well as generator development using high capacity adsorbents for Mo to be employed with low to medium specific activity Mo-99 for application and distribution among IAEA Member States.

Novel nano/micro/bio sorbents for development of high capacity generators (US Patent; 20130039822 A1).

Overall Objective

This new CRP will seek to formulate guidelines to enhance and strengthen the expertise and capability of Member States in developing the new production method of Mo-99 (based on photodynamic reaction), and also the optimization of existing low-to-medium specific activity generators using high capacity absorbents for Mo in order to meet national needs.

Specific Objectives will include:

  • Producing guidelines for the production of Mo-99 using linear accelerators through the Mo-100(g,n)Mo-99 reaction;
  • The optimization of available generators using auxiliary instruments;
  • Application of new adsorbents with high capacity for Mo;
  • Application of new optimized technical approaches to separate Tc-99m from Mo-99 such as electrochemical method as well as liquid extraction.

How to join the CRP?

Please submit your Proposal for Research Contract or Agreement by August 1st, 2017 directly to the IAEA’s Research Contracts Administration Section, using the form templates on the CRA pages (preferably via email). For further information related to this CRP, potential applicants could contact Joao A. Osso, Jr. and Amir R. Jalilian, Project Officers, Radioisotope Products and Radiation Technology Section, Division of Physical and Chemical Sciences, Department of Nuclear Science and Applications, IAEA.

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