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New Project to Optimize Human Milk Intake Research in Infants

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Annie Spratt/Unsplash

The IAEA is launching a new coordinated research project to advance global maternal and child health by optimizing the dose-to-mother deuterium oxide method—a stable (non-radioactive) isotope technique used to measure breast milk intake in infants. This project will generate critical data on maternal predictors of breastfeeding success, expand the IAEA’s global human milk intake database and refine the method for higher accuracy.

In the first six months of life, breastfeeding is often the main source of nutrition for infants, providing protection against malnutrition, infections and chronic diseases. For mothers, it supports recovery after birth and reduces long-term health risks. Yet globally, only 44 per cent of infants under six months are exclusively breastfed.

Even when mothers are malnourished, they produce sufficient amounts of breast milk, which remains the best possible nutrition for their babies even though micronutrients levels may be affected. However, the perception that milk supply is insufficient and other challenges can lead some mothers to stop breastfeeding early. The dose-to-mother (DTM) deuterium oxide method can help address this issue by quantifying actual breast milk intake, providing stakeholders with reliable data.

How the DTM method works: Assessing intake of Human Milk in Breastfed infants | IAEA

“Understanding maternal predictors of breastfeeding can help to tailor interventions that promote and maintain breastfeeding practices,” said Cornelia Loechl, Head of the IAEA’s Nutritional and Health-Related Environmental Studies Section.

The IAEA’s new coordinated research project will build on the IAEA  database on human milk intake, which includes a global collection of around 4000 DTM datapoints from 27 countries. Specific research objectives include: optimizing the DTM method, generating new data for the database that will help bridge regional and age-related data gaps, and identifying key maternal factors affecting breastfeeding success.

How to join this CRP

The CRP is open to all Member States. Participating institutions should have:

  • Experience in stable isotope techniques for nutrition research.
  • Fieldwork capabilities and access to healthcare institutions for participant recruitment.
  • Preferred: Experience in longitudinal studies and interventions addressing maternal stressors.

Research institutions interested in joining the CRP must submit their Proposal for Research Contract or Agreement via email, no later than 15 June 2025, to the IAEA’s Research Contracts Administration Section, using the appropriate template on the CRA web portal. The same template can be used for both the research contract and technical contract. The IAEA encourages institutes to involve, to the extent possible, women and young researchers in their proposals.

For further information related to this CRP, potential applicants should use the contact form on the CRP page.

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