Instructive Surfaces and Scaffolds for Tissue Engineering Using Radiation Technology. (Conducted Jointly with E31007)

Closed for proposals

Project Type

Coordinated Research Project

Project Code

F23030

CRP

1965

Approved Date

13 September 2013

Status

Closed

Start Date

13 February 2014

Expected End Date

30 April 2019

Completed Date

24 September 2020

Description

This CRP will support interested institutions in preparation and testing of instructive scaffolds and surfaces using radiation technology to create tissue grafts and help to decrease the need for human donors. It would also be considered as a forum for information, knowledge, and technology exchange among participating institutions and facilitate the formation of a network between the diverse disciplines involved. Radiation technologies plays a role in facilitating and accelerating the development of tissue engineering by addressing some of its challenges and opportunities, such as preparation/optimization of instructive scaffolds and their sterilization. The CRP is jointly conducted by the Division of Physical and Chemical Sciences (NAPC) and the Division of Human Health (NAHU). While NAPC will implement the part related to the development and testing of the instructive surfaces and scaffolds, NAHU will carry out the biomedical application part related to the end-uses of the instructive surfaces and scaffolds.

Objectives

is to engineer instructive scaffolds and surfaces using radiation technology to create tissues from autologous and allogeneic human somatic cells to provide tissue grafts and decrease the need for human donors.

Specific objectives

To bring together researchers from different research directions with end-users

To investigate and optimize the preparation of instructive scaffolds and surfaces

To investigate the use of radiation sterilization of the new instructive scaffolds and decellularized matrices

To study cell-cell-scaffold-matrix-ECM interaction

To study the possibilities and effectiveness of combining biological and non-biological materials on regeneration/repair

Impact

This CRP supported interested institutions in preparation and testing of instructive scaffolds and surfaces using radiation technology to create tissue grafts and help to decrease the need for human donors. It would also be considered as a forum for information, knowledge, and technology exchange among participating institutions and facilitate the formation of a network between the diverse disciplines involved. Radiation technologies plays a role in facilitating and accelerating the development of tissue engineering by addressing some of its challenges and opportunities, such as preparation/optimisation of instructive scaffolds and their sterilisation. The CRP is jointly conducted by the Division of Physical and Chemical Sciences (NAPC) and the Division of Human Health (NAHU). While NAPC (F23030) will implement the part related to the development and testing of the instructive surfaces and scaffolds, NAHU (E31007) will carry out the biomedical application part related to the end-uses of the instructive surfaces and scaffolds.

Relevance

Human tissue, autologous and allogeneic, is an important resource for medical treatment. For example, such tissues are used in burn treatments, reconstructive surgery, cancer care, and skin replacements.
One source of human tissue, tissue banking, exists primarily because of the generosity and goodwill of tissue donors and their families. However, many countries face a shortage of donor tissues/organs due to religious concerns, lack of donor registration programs, fiscal constraints, etc. Shortage of donor tissue drives the needs for technologies to enhance healing and tissue reconstruction. Tissue engineering promises the development of new tissue created either from “cultured” cells (including stem cells) or by directing and guiding the body’s own regenerative mechanisms. Tissue engineering can be facilitated by synthetically produced bio-materials and make use of nanotechnology. Tissue engineering, whether or not combined with traditional tissue banking techniques might solve the shortage of donor material in the future and lead to true regenerative tissue and organ replacement.
Radiation technologies play a role in facilitating and speeding up the development of tissue engineering by addressing some of its challenges and opportunities. These include preparation/optimisation of instructive scaffolds, preparation of gels, surface grafting, inhibition of cell growth in stem cell feeder layers and sterilisation. A number of methods can be used to generate instructive matrices to be employed in tissue engineering. Among them, the application of radiation technology for formation and modification of surfaces and matrices has remarkable advantages such as: initiation of low temperature reactions, absence of harmful initiators, high penetration through the bulk materials and curing of different types of polymeric materials (by polymerisation, grafting and cross-linking). Additionally, radiation synthesised surfaces and scaffolds might simultaneously be modified and sterilised. Radiation sterilisation is a well-established technology. It is a reliable and effective process used industrially for nearly 60 years. Medical devices, raw materials for pharmaceuticals, bio-materials, tissue allografts, and cosmetics among other products are routinely sterilised by ionising radiation.

CRP Publications

Type

Conference paper

Year

2016

Description

J.M. Rosiak, P. Ulanski Radiation engineering of polymeric biomaterials IRaP 2016 – The 12th International Symposium of Ionizing Radiation & Polymers, 25-30.09. 2016, Presqu’île de Giens, France

Country/Organization

Poland

Type

Scientific paper

Year

2017

Description

Rana MM, Akhtar N, Rahman MS, Jamil HM, Asaduzzaman SM. Extraction of Hydroxyapatite from Bovine and Human Cortical Bone by thermal decomposition and effect of gamma radiation: A comprehensive study. International Journal of Complementary & Alternative Medicine 8(3):00263

Country/Organization

Bangladesh

Type

Conference paper

Year

2017

Description

J. M. Rosiak Radiation formation of hydrogel biomaterials 26th Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.10.2017, Rytro, Polska

Country/Organization

Poland

Type

Scientific paper

Year

2016

Description

Synthesis of papain nanoparticles by electron beam irradiation – A pathway for controlled enzyme crosslinking Varca, G.H.C., Kadlubowski, S., Wolszczak, M., (...), Rosiak, J.M., Ulanski, P. International Journal of Biological Macromolecules 92; 654-659, (2016).

Country/Organization

Poland

Type

Scientific paper

Year

2018

Description

Radiation synthesis of biocompatible hydrogels of dextran methacrylate Szafulera, K., Wach, R.A., Olejnik, A.K., Rosiak, J.M., Ulanski, P. Radiat. Phys. Chem., 142, pp. 115-120 , (2018)

Country/Organization

Poland

Type

Conference paper

Year

2017

Description

S. Kadlubowski, P. Ulanski, J. M. Rosiak Radiation-induced synthesis of polymeric nanogels 26th Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.10. 2017, Rytro, Polska

Country/Organization

Poland

Type

Scientific paper

Year

2016

Description

Thermoresponsive poly[tri(ethylene glycol) monoethylether methacrylate]-peptide surfaces obtained by radiation grafting—synthesis and characterization A. Adamus J. Komasa S. Kadlubowski P. Ulanski J.M. Rosiak M. Kawecki A. Klama-Baryla A. Dworak B.Trzebicka R. Szweda Colloids and Surfaces B: Biointerfaces, 145, 185-193, (2016)

Country/Organization

Poland

Type

Conference paper

Year

2017

Description

A. Bauer, B. Rokita, S. Kadlubowski, P. Ulanski Influence of ionizing radiation on metformin in aqueous solution The 30th Miller Conference on Radiation Chemistry, 7-11.10.2017, Castellammare del Golfo, Italy

Country/Organization

Poland

Type

Scientific paper

Description

Xiangmei Zhang, Yaqing Zhang, Wenqiang Chen, Ling Xu*, Shicheng Wei,Yufeng Zheng, Maolin Zhai. Biological Behavior of FibroblastXiangmei Zhang, Ling Xu*, Shicheng Wei, Maolin Zhai, Jiuqiang Li. Stimuli Responsive Deswelling of Radiation Synthesized Collagen Hydrogel in Simulated Physiological Environment. Journal of Biomedical Materials Research: Part A, 2013, 101A(8):2191-2201.(corresponding author)

Country/Organization

China

Type

Conference paper

Year

2016

Description

K. Szafulera, R.A. Wach, P. Ulanski Radiacyjna synteza hydrozelu z metakrylanu dekstranu XVII Zjazd Polskiego Towarzystwa Badan Radiacyjnych im. Marii Sklodowskiej – Curie, 27-30.09. 2016, Siedlce, Polska

Country/Organization

Poland

Type

Conference paper

Year

2015

Description

A. Wach, J. Cala, K. Kowalska-Ludwicka, Ch. Aranilla, A. Adamus, A.K. Olejnik, Z. Pasieka, J.M. Rosiak, P. Ulanski Nerve guidance channels of synthetic biodegradable polymers with internal hydrogel scaffold of radiation-crosslinked polysaccharide 27th European Conferences on Biomaterials, Cracow (Poland) 30.08 – 3.09.2015

Country/Organization

Poland

Type

Book chapter

Year

2017

Publication URL

http://link.springer.com/article/10.1007/s41061-016-0092-5

Description

Chitosan-based Matrices prepared by gamma irradiation for tissue regeneration: Structural properties vs. Prepared Method

Country/Organization

Portugal

Type

Conference paper

Year

2016

Description

A. Adamus, J. Komasa, S. Kadlubowski, P. Ulanski, J. M. Rosiak, M. Kawecki, A. Klama-Baryla, M. Nowak, J. Glik, D. Kitala, W. Labus, A. Dworak, B. Trzebicka, R. Szweda Thermoresponsive poly[tri(ethyleneglycol) monoethylethermethacrylate]-peptide surfaces obtained by radiation grafting – synthesis and characterization POLYMAT 2016 – Silesian Meetings on Polymer Materials, 27-28.06. 2016, Zabrze, Poland

Country/Organization

Poland

Type

Conference paper

Year

2016

Description

K. Szafulera, R.A. Wach, P. Ulanski, J.M. Rosiak Radiation synthesis of hydrogels of dextran methacrylate IRaP 2016 – The 12th International Symposium of Ionizing Radiation & Polymers, 25-30.09. 2016, Presqu’île de Giens, France

Country/Organization

Poland

Type

Conference paper

Year

2017

Description

R. A. Wach, K. Szafulera, J. M. Rosiak, P. Ulanski Radiation induced reaction in polysaccharides – crosslinking The 30th Miller Conference on Radiation Chemistry, 7-11.10.2017, Castellammare del Golfo, Italy

Country/Organization

Poland

Type

Conference paper

Year

2016

Description

R.A. Wach, W. Mozalewska, M. Ramos Gallego, J. Vange, A.W. Bosman, T. Mes In vitro biodegradation of e-spun mesh based on supramolecular UPy chemistry 10th World Biomaterials Congress, 17-22.05. 2016, Montreal, Canada

Country/Organization

Poland

Type

Conference paper

Year

2017

Description

R. A. Wach, J. M. Rosiak, P. Ulanski Polysaccharides hydrogel – radiation induced formation and medical applications 26th Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.10. 2017, Rytro, Polska

Country/Organization

Poland

Type

Conference paper

Year

2015

Description

R. Czechowska-Biskup, R.A. Wach, P. Ulanski, J.M. Rosiak Formation of chitosan and carboxymethyl chitosan hydrogels by ionizing radiation Physics and Chemistry in Polysaccharide Science:From Molecules to Materials, Joint COST Action FP1205/EPNOE Meeting, Warsaw (Poland) 18.10.2015

Country/Organization

Poland

Type

Scientific paper

Year

2017

Description

Rana MM, Akhtar N, Rahman MS, Hasan MZM, Asaduzzaman SM. Extraction and Characterisation of Hydroxyapatite from Bovine Cortical Bone and Effect of Radiation. International Journal of Biosciences 11 (3): 20-30.

Country/Organization

Bangladesh

Type

Conference paper

Year

2016

Description

R.A. Wach, W. Mozalewska, A. Adamus, A.K. Olejnik, M. Ramos Gallego, J. Vange, A.W. Bosman, T. Mes, J.M. Rosiak Sterilization of a biodegradable medical device comprising supramolecular polymers – is radiation technique appropriate? IRaP 2016 – The 12th International Symposium of Ionizing Radiation & Polymers, 25-30 .09.2016, Presqu’île de Giens, France

Country/Organization

Poland

Type

Conference paper

Year

2016

Description

W. Mozalewska, R. Czechowska-Biskup, A.K. Olejnik, R.A. Wach, J.M. Rosiak Chitosan-containing hydrogel dressing prepared by radiation technique IRaP 2016 – The 12th International Symposium of Ionizing Radiation & Polymers, 25-30 September 2016, Presqu’île de Giens, France

Country/Organization

Poland

Type

Scientific paper

Year

2017

Description

Chitosan-containing hydrogel wound dressings prepared by radiation technique Mozalewska, W., Czechowska-Biskup, R., Olejnik, A.K., Ulanski, P., Rosiak, J.M. Radiat. Phys. Chem. 134, 1-7, (2017).

Country/Organization

Poland

Type

Conference paper

Year

2018

Publication URL

http://indico.sinap.ac.cn/e/apsrc2018.html.

Description

"Radiation Crosslinked Gelatin/Sodium Alginate/Carboxymethylcellulose Sodium Hydrogel for the Application as Debridement Glue". (The 7th Asian-Pacific Symposium on Radiation Chemistry APSRC 2018, Nov.4-8, 2018, Shanghai, China.)

Country/Organization

China

Type

Scientific paper

Year

2014

Description

Xiangmei Zhang, Yaqing Zhang, Wenqiang Chen, Ling Xu*, Shicheng Wei,Yufeng Zheng, Maolin Zhai. Biological Behavior of Fibroblast on Contractile Collagen Hydrogel Crosslinked by ?-Irradiation. Journal of Biomedical Materials Research: Part A(2014)102:2669–2679

Country/Organization

China

Type

Conference paper

Year

2017

Description

R. A. Wach, W. Mozalewska, A. Adamus-Wlodarczyk, R. Czechowska-Biskup, S. Kadlubowski, A. K. Olejnik, B. Rokita, P. Ulanski, J. M. Rosiak Bioactive hydrogel wound dressing 28th Annual Conference of the European Society of Biomaterials (ESB), 4-8.09. 2017, Ateny, Greece

Country/Organization

Poland

Type

Conference paper

Year

2017

Description

Rana MM, Akhtar N, Asaduzzaman SM, Fabrication and Characterisation of Bio-compatible 3D Porous Composite Scaffold for Bone Tissue Engineering. BABG 1st National Congress,28 April 2017,Dhaka, Bangladesh, poster no-12, page-33 (Poster presentation)

Country/Organization

Bangladesh

Type

Scientific paper

Year

2017

Description

Rana MM, Akhtar N, Hasan MZ, Asaduzzaman SM. Preparation and evaluation of Bio-compatible composite for bone tissue engineering, SSRG International Journal of Pharmacy and Biomedical Engineering 4 (6): 8-15

Country/Organization

Bangladesh

Type

Scientific paper

Year

2017

Description

"Controlling of hydrophilic/hydrophobic balance on polstyrene cell culture dish surfaces by RAFT-mediated, radiation-induced grafting for quick recovery of cell sheets" Invited lecture given at the 5th OBI-Biomaterials Conference, 20-24 August 2017, Maresias, Sao Paulo, Brasil.

Country/Organization

Turkey

Type

Scientific paper

Year

2014

Description

Radiation grafting of oligo(ethylene glycol) ethyl ether methacrylate on polypropylene J. Komasa, A. Milek, P. Ulanski, J.M. Rosiak Radiation Physics and Chemistry 94; 137-140 (2014)

Country/Organization

Poland

Type

Scientific paper

Year

2018

Description

Tingrui Lin, Qingwen Bai, Jing Peng, Ling Xu, Jiuqiang Li, Maolin Zhai. One-step radiation synthesis of agarose/polyacrylamide double-network hydrogel with extremely excellent mechanical properties. Carbohydrate Polymers, 2018, 200, 72-81.

Country/Organization

China

Type

Colloquium

Year

2019

Description

Qolloqium BTS 22 July 2019, Malaysian Nuclear Agency

Country/Organization

Malaysia

Type

Conference paper

Year

2016

Description

K. Szafulera, R. A. Wach, A. K. Olejnik, P. Ulanski Dextran-based hydrogels for biological applications: synthesis and characterization BioChemMed Session, 25-27.11. 2016, Gdansk, Poland

Country/Organization

Poland

Type

Conference paper

Year

2015

Description

R.A. Wach, J. Cala, A. Adamus, A.K. Olejnik, Z. Pasieka, J.M. Rosiak, P. Ulanski Synthetic biodegradable polymers with internal hydrogel scaffold of radiation-crosslinked polysaccharide as nerve regeneration conduit 3rd International Symposium on Peripheral Nerve Regeneration, Hannover (Germany) 24-25.09.2015

Country/Organization

Poland

Type

Conference paper

Country/Organization

Poland

Type

Scientific paper

Year

2015

Publication URL

http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSea…

Description

Yaqing Zhang, Xiangmei Zhang, Ling Xu*, Shicheng Wei* and Maolin Zhai. Radiation crosslinked collagen/dextran dermal scaffolds: effects of dextran on crosslinking and degradation. Journal of Biomaterials Science, Polymer Edition, 2015,26 (3): 162–180

Country/Organization

China

Type

Scientific paper

Year

2017

Description

Sultana T, Rana MM, Akhtar N, Hasan MZ, Talukder AH, Asaduzzaman SM. Preparation and Physicochemical chrarterization of Nano-Hydroxyapatite based 3D Porous Scaffold for Biomedical application. Advances in Tissue engineering & Regenerative Medicine: Open Access 3 (3):00065

Country/Organization

Bangladesh

Type

Scientific paper

Year

2016

Description

Synthesis of chitosan and carboxymethyl chitosan hydrogels by electron beam irradiation Czechowska-Biskup, R., Wach, R.A., Stojek, P., Kaminska, M., Rosiak, J.M., Ulanski, P. Progress on Chemistry and Application of Chitin and its Derivatives, 21, pp. 27-45, (2016)

Country/Organization

Poland

Type

Seminar

Year

2018

Description

Marina Talib, Rida Tajau , Siti Nurul Syafika Sheikh Ibrahim, Nurhidayah Noor Effendy. Determining Layer Control Of Photopolymerization Systems For Fabrication Of 3D Structure. Seminar R&D Nuclear Malaysia 2018. 42. 30 Oktober-2 November 2018.

Country/Organization

Malaysia

Type

Conference paper

Year

2015

Description

R. A. Wach, J. Cala, A. Adamus, A.K. Olejnik, B. Grobelski, Z. Pasieka, J.M. Rosiak, P. Ulanski Carboxymethylchitosan hydrogel as internal scaffold of peripheral nerve regeneration conduit Polysacharides and polysacharide – based advances materials:from science to industry. 4th EPNOE Intenationak Polysaccharide Conferences, Warsaw (Poland) 19-22.10.2015

Country/Organization

Poland

Type

Scientific paper

Year

2018

Publication URL

http://doi.org/10.3390/ma11122535

Description

Chitosan/polyvynylpyrrolidone matrices obtained by gamma irradiation for skin scaffolds:charaterisation and preliminary cell response studies.

Country/Organization

Portugal

Type

Scientific paper

Year

2016

Publication URL

http://dx.doi.org/10.1016/j.radphyschem.2015.03.027

Description

2-(2-methoxyethoxy)ethylmethacrylate hydrogels with gradient of cross-link density Slawomir Kadlubowski, Malgorzata Matusiak, Agnieszka Adamus, Magdalena N.Olejniczak, Marcin Kozanecki Radiation Physics and Chemistry 118, 107–110, (2016)

Country/Organization

Poland

Type

Conference paper

Year

2016

Description

S. Kadlubowski, A. Adamus, D. Kitala, A. Klama-Baryla, M. Kawecki, W. Labus, J. Glik, M. Nowak, P. Ulanski Radiation synthesis of hydrogel-based matrix for tissue cultivation ICIP2016 – International Conference on Ionizing Processes, 10-14.10.2016, Brookhaven National Laboratory, USA

Country/Organization

Poland

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