Nanosized Delivery Systems for Radiopharmaceuticals

Closed for proposals

Project Type

Coordinated Research Project

Project Code

F22064

CRP

2002

Approved Date

13 November 2013

Status

4 - Closed

Start Date

4 April 2014

Expected End Date

4 April 2019

Completed Date

29 October 2019

Participating Countries

Argentina
Brazil
Egypt
Iran (Islamic Republic of)
Italy
Malaysia
Mexico
Pakistan
Poland
Singapore
Thailand
United States of America

Description

The aim of this CRP is to provide significant improvement in the delivery of therapeutic radiopharmaceuticals through the use of nanotechnology. It is expected to result in new nanoparticles capable of forming stable bonds with diagnostic and therapeutic radioisotopes, and with tumour specific biomolecules and proteins (including monoclonal antibodies) leading to well-defined delivery devices. Such nano constructs built from radiation-synthesized polymeric nano particles could be potentially capable of reaching and selectively penetrating the tumour sites, thus affording highly effective molecular imaging and therapeutic tools to combat various forms of human cancers. The proposed CRP will provide tremendous benefits to MS because the nanosized diagnostic and therapeutic agents that are planned to be developed might be potentially used in alleviating pain and suffering of human patients globally.

Specific objectives

a; To synthesize polymeric (both synthetic and natural) nanoparticles capable of forming in vitro and in vivo-stable bonds, through chelate interactions, with diagnostic and therapeutic radioisotopes—for the creation of new generation of nanoparticle-based tumor specific radiopharmaceuticals.

b; To formulate tumor specific proteins (including monoclonal antibodies) and generate well-defined nanoparticles, through radiation methods, for use in conjugation reactions with diagnostics and therapeutic radioisotopes for the generation of nanosized tumor specific radiopharmaceuticals.

c; To formulate nanoparticles derived from inherently diagnostic/ therapeutic radioisotopes and to conjugate them with tumor specific peptide(s)—in order to generate radioactive nanoceuticals for diagnostic imaging and therapy.

d; To develop a functional in vivo platform for efficient testing of various radiolabeled nanoconstructs using animal models that mimic human tumors—all aimed at clinical translation of diagnostic/therapeutic efficacy from animal for human applications.

Impact

The participants suggested initiation of a new CRP for completion of preclinical studies of the selected nanoconstructs (with focus on Ga-68, Lu-177 and Au-198 radionuclides)
The participants emphasized on initiation of a new CRP on one selected nanoconstruct from this CRP (MGF 198AuNPs)with completed preclinical results) through IAEA NAHU, nuclear medicine section
Instant initiation of an IAEA publication on the ‘Development of radiolabeled nanoparticles for theranostic applications” as an outcome of this CRP with the help of the participants and world-class scientists
Preparation of an IAEA publication on “Guidelines on the development of human tumour models for preclinical studies of radiopharmaceuticals”
A new activity on the clinical evaluation of chemical and radiation produced 99mTc-Nanocolloids for sentinel node scintigraphy through IAEA NAHU, nuclear medicine section
The participants agreed that the report to be kept confidential among the participants and not to be shared publicly. As soon as the participants announce their willingness for public access, the scientific secretary will initiate publishing the report as a ‘working material”

Relevance

The currently used therapeutic agents in nuclear medicine continue to pose medical challenges mainly due to the limited uptake of radiocompound within tumour sites. This limited accumulation accounts for the fact that current beta-emitting therapeutic nuclear medicine agents have failed to deliver optimum therapeutic payloads at tumour sites. Actually, no other radiolabelled therapeutic agent has been capable to get close to the remarkably high target accumulation that was demonstrated by the long-lasting radionuclide I-131 in thyroid cancer. This means that metastases of several different types of aggressive cancers cannot be controlled, making it difficult to treat cancer patients. Therefore, new delivery modalities that result in (i) effective delivery of therapeutic probes with optimum payloads, site specifically at the tumour sites, minimal/tolerable systemic toxicity, and (ii) higher tumour retention, would bring about a clinically measurable shift in the way cancers are diagnosed and treated.
Nanotechnology has the potential to bring about this paradigm shift in the early detection and therapy of various forms of human cancers because radioactive nanoparticles of optimum sizes for penetration across tumour cell membranes can be engineered through a myriad of interdisciplinary approaches, involving teams of experts from nuclear medicine, materials sciences, physics, chemistry, tumour biology and oncologists. Therefore, the overall approach which encompasses application of nanoparticulate radioactive probes in combination with polymeric nanomaterials has a realistic potential to generate the next generation of tumour specific theranostic nanoradiopharmaceuticals and minimize/eliminate delivery and tumour accumulation problems associated with the existing traditional nuclear medicine agents.

CRP Publications

Type

full paper

Year

2019

Description

Flores CY, H LJM, Achilli E, Schinca DC, Grasselli M. Plasmon properties of multilayer albumin/gold hybrid nanoparticles. Materials Research Express. 2019;6(5):55005. doi: 10.1088/2053-1591/aaedd8.

Country/Organization

Argentina

Type

GRADUATED STUDENT THESIS

Year

2018

Description

MOHAMED ABOZEID, PhD Thesis “Imaging and Radioimmunotheraphy of Pancreatic Cancer”

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2013

Description

KEDZIOR JOANNA, MSc Thesis “Radiation synthesis of stabilized silver nanoparticles - process optimization”

Country/Organization

POLAND

Type

full paper

Year

2019

Description

Synthesis and Biodistribution Study of Biocompatible 198Au Nanoparticles by use of Arabinoxylan as Reducing and Stabilizing Agent, ACCEPTED in “Biological Trace Element Research”, manuscript #: BTER-D-18-01156

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2015

Description

MARILENA SPERA, BSc Degree Thesis “Nanoparticelle d’oro: sintesi, proprietà ed applicazioni emergenti”.

Country/Organization

ITALY

Type

full paper

Year

2018

Description

Freitas de Freitas L, Varca GHC, Dos Santos Batista JG, Benévolo Lugão A. An Overview of the Synthesis of Gold Nanoparticles Using Radiation Technologies. Nanomaterials (Basel, Switzerland). 2018;8(11):939. doi: 10.3390/nano8110939.

Country/Organization

BRAZIL

Type

full paper

Year

2016

Description

WONGKRONSAK, S., TANGTHONG, T., PASANPHAN, W., “Electron beam induced water-soluble silk fibroin nanoparticles as a natural antioxidant and reducing agent for a green synthesis of gold nanocolloid”, Radiat. Phys. Chem. 118 (2016) 27–34.

Country/Organization

Thailand

Type

GRADUATED STUDENT THESIS

Year

2019

Description

ARYEL HEITOR FERREIRA, PhD ThesisEvaluation of protein-based nanoparticles as potentials diagnostic agents.

Country/Organization

BRAZIL

Type

GRADUATED STUDENT THESIS

Year

2016

Description

MAKASEWICZ KATARZYNA, M.Sc Thesis “Radiation synthesis of poly(ethyleneimine) nanogels - thesis with collaboration with Palermo”

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2015

Description

ROBERTA ROSALIA RUSSO, MSc Thesis “Trasporto e rilascio intracellulare di antimiR nella Terapia Oncologica”.

Country/Organization

ITALY

Type

full paper

Year

2019

Publication URL

https://www.sciencedirect.com/science/article/pii/S0969806X18311563

Description

M. Matusiak, S. Kadlubowski, J.M. Rosiak, Nanogels synthesized by radiation-induced intramolecular crosslinking of water-soluble polymers, Radiation Physics and Chemistry, 2019, https://doi.org/10.1016/j.radphyschem.2018.12.019

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2018

Description

JESSICA LEAL, MSc Thesis "Synthesis and characterization of radioactive gold nanoparticle (198Au-NPs) with BSA for biomedical purposes”

Country/Organization

BRAZIL

Type

GRADUATED STUDENT THESIS

Year

2019

Description

JORGE GABRIEL S. BATISTA, PhD Thesis Synthesis, characterization and functionalization of gold nanoparticles for application in cancer diagnosis and therapy

Country/Organization

BRAZIL

Type

full paper

Year

2019

Description

Al-Yasiri AY. Katti, K.V., Loyalka, S, et al, Estimation of Tumor and Local Tissue Dose in Gold Nanoparticles Radiotherapy for Prostate Cancer.; Practical Oncology and Radiotherapy, 2019 (In Press)

Country/Organization

USA

Type

GRADUATED STUDENT THESIS

Year

2017

Description

RARIVOSON ELONGE, M.Sc Thesis “Synthesising and studies of gold nanoparticles combined with biomass-derived compounds”

Country/Organization

POLAND

Type

Research paper

Year

2015

Publication URL

http://www.ncbi.nlm.nih.gov/pubmed/26369025

Description

Orocio-Rodríguez, E., Ferro-Flores, G., Santos-Cuevas, C. L., Ramírez, F. D. M., Ocampo-García, B. E., Azorín-Vega, E., & Sánchez-García, F. M. (2015). Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging. Journal of Nanoscience and Nanotechnology,15(6), 4159-4169.

Country/Organization

Mexico

Type

GRADUATED STUDENT THESIS

Year

2019

Description

MOAMEN MOHAMED SOLIMAN, MSc Thesis “Nano Sized Delivery For Radiopharmaceuticals”

Country/Organization

EGYPT

Type

full paper

Year

2017

Description

Siri M, Achilli E, Grasselli M, Alonso SV. Albumin nanocarriers, ?- irradiated crosslinked, combined with therapeutic drugs for cancer therapy. Current pharmaceutical design. 2017;23(35):5272-82. doi: 10.2174/1381612823666170615105909

Country/Organization

Argentina

Type

full paper

Year

2018

Description

Santos JJ, Leal J, Dias LAP, Toma SH, Corio P, Genezini FA, et al. Bovine Serum Albumin Conjugated Gold-198 Nanoparticles as Model To Evaluate Damage Caused by Ionizing Radiation to Biomolecules. ACS Applied Nano Materials. 2018;1(9):5062-70. doi: 10.1021/acsanm.8b01174.

Country/Organization

BRAZIL

Type

full paper

Year

2015

Description

Pasanphan W, Rattanawongwiboon T, Choofong S, Güven O, Katti KK. Irradiated chitosan nanoparticle as a water-based antioxidant and reducing agent for a green synthesis of gold nanoplatforms. Radiation Physics and Chemistry. 2015;106:360-70.

Country/Organization

USA

Type

GRADUATED STUDENT THESIS

Year

2015

Description

FEDERICO ANTONINI, MSc Thesis “Radiation Synthesis and charcterisation of PVP based nanogels (Research activity carried out in POLAND-Lodz”

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2019

Description

MALIHE HAJIRAMEZANALI, PhD Thesis “ Preparation of Radiolabeled Bombesin Nanoparticles for In Vivo Gastrin-Releasing Peptide Receptor Imaging”

Country/Organization

IRAN

Type

GRADUATED STUDENT THESIS

Year

2016

Description

ESMAIL MOLLARAZI, PhD Thesis “Development of Folate ConjugatedC nanoparticles for Theranostic Applications”

Country/Organization

IRAN

Type

full paper

Year

2019

Description

Ocampo-García, B., Gibbens-Bandala, B., Morales-Avila, E., Melendez-Alafort, L., Khoobchandani, M., Trujillo-Nolasco, M., & Katti, K. V. (2019). Dual-Targeted Therapy and Molecular Imaging with Radiolabeled Nanoparticles. In Biotechnology Products in Everyday Life (pp. 201-219). Springer, Cham.

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2017

Description

LORENA ANNA DITTA, PhD Thesis “Ionizing radiation synthesis of multifunctional nanogels for biomedical applications”

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2016

Description

SOWINSKI SEBASTIAN, M.Sc Thesis “ Radiolysis of papain in aqueous solutions

Country/Organization

POLAND

Type

AWARDS

Year

2014

Description

Awarded Thesis. 2014, ROSALBA MONSERRAT MIRANDA OLVERA, B.Sc. Thesis (Sistema multivalente para la terapia de linfomas no-Hodking basado en Anti CD-20 conjugado a nanopartículas de oro).

Country/Organization

MEXICO

Type

full paper

Year

2017

Description

Katti KV. Al-Yasiri AY, Khoobchandani M, Cutler CS, Watkinson L, Carmack T, Smith CJ, et al. Mangiferin functionalized radioactive gold nanoparticles (MGF-(198)AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy. Dalton transactions (Cambridge, England : 2003). 2017;46(42):14561-71.

Country/Organization

USA

Type

full paper

Year

2017

Publication URL

https://www.sciencedirect.com/science/article/pii/S0969806X16305977

Description

M. Matusiak, S. Kadlubowski, P. Ulanski, Radiation induced synthesis of poly(acrylic acid) nanogels, Radiation Physics and Chemistry, 142, 2018, 125-129, DOI:10.1016/j.radphyschem.2017.01.037,

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2019

Description

RURARZ BEATA, Ph.D Thesis “Polymer-based nanocarriers of biologically active compounds”

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2018

Description

ZIOMEK GABRIELA, B.Sc Thesis “Sonochemical synthesis of gold nanoparticles

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2016

Description

BRENDA VIANEY GIBBENS BANDALA, MSc. Thesis “Síntesis y caracterización de nanopartículas poliméricas de polimetilmetacrilato (PMMA) conjugadas con -RGD- para el transporte y liberación de paclitaxel”

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2019

Description

ADRIANA K. CAVALCANTE, PhD Thesis “Acute toxicity study of gold nanoparticles in Danio rerio”

Country/Organization

BRAZIL

Type

full paper

Year

2015

Description

51. Esmail Mollarazi, Amir R. Jalilian, Fariba Johari-daha, Fatemeh Atyabi, Development of 153Sm-folate-PEI conjugated chitosan nanoparticles for targeted therapy purposes, J. Label Compd. Radiopharm 2015, 58 327–335.

Country/Organization

Iran

Type

full paper

Year

2017

Description

Flores CY, Achilli E, Grasselli M. Radiosynthesis of Gold/Albumin Core/shell Nanoparticles for Biomedical Applications. MRS Advances. 2017;2(49):2675-81. doi: 10.1557/adv.2017.527.

Country/Organization

Argentina

Type

Research paper

Year

(2014).

Description

Ocampo García B.E., Miranda-Olvera R.M., Santos-Cuevas C.L., García-Becerra R., Azorín-Vega E.P., Ordaz-Rosado D., (2014). In vitro Decrease of the BCL-2 Protein Levels in Lymphoma Cells Induced by Gold Nanoparticles and Gold Nanoparticles-Anti-CD20, Nanoscience & Technology, 1(3): 1-6

Country/Organization

Mexico

Type

GRADUATED STUDENT THESIS

Year

2014

Description

PASZKOWSKA ANNA, BSc Thesis “Stabilization of metals nanoparticles generated by irradiation using polymers”

Country/Organization

POLAND

Type

full paper

Year

2018

Description

Fazolin GN, Varca GHC, Kadlubowski S, Sowinski S, Lugão AB. The effects of radiation and experimental conditions over papain nanoparticle formation: Towards a new generation synthesis. Radiation Physics and Chemistry. 2018. doi: 10.1016/j.radphyschem.2018.08.033.

Country/Organization

BRAZIL

Type

full paper

Year

2015

Description

Orocio-Rodríguez, E., Ferro-Flores, G., Santos-Cuevas, C. L., Ramírez, F. D. M., Ocampo-García, B. E., Azorín-Vega, E., & Sánchez-García, F. M. (2015). Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging. Journal of Nanoscience and Nanotechnology,15(6), 4159-4169.

Country/Organization

MEXICO

Type

full paper

Year

2018

Description

K. V. Katti, M. Khoobchandani, V. C. Thipe, A. Y. Al-Yasiri, K. K. Katti, S. K. Loyalka, T. M. Sakr, A. B. Lugão. Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles. Journal of Radioanalytical and Nuclear Chemistry. 2018;318(3):1737-47.

Country/Organization

USA

Type

GRADUATED STUDENT THESIS

Year

2019

Description

GABRIELA N. FAZOLIN, MSc Thesis “Radiation-induced synthesis of bioactive papain-based nanocarriers for radiopharmaceuticals delivery”

Country/Organization

BRAZIL

Type

GRADUATED STUDENT THESIS

Year

2017

Description

KIANDOKHT AMIRI, MSc Thesis “Resveratrol functionalized Gold Nanoparticles in Imaging and Therapy

Country/Organization

USA

Type

full paper

Year

2017

Description

Ancira-Cortez A, Morales-Avila E, Ocampo-García BE, González-Romero C, Medina LA, López-Téllez G, et al. Preparation and Characterization of a Tumor-Targeting Dual-Image System Based on Iron Oxide Nanoparticles Functionalized with Folic Acid and Rhodamine. Journal of Nanomaterials. 2017; 2017. https://www.hindawi.com/journals/jnm/2017/5184167/abs/

Country/Organization

MEXICO

Type

full paper

Year

2018

Description

Queiroz RG, Varca GHC, Kadlubowski S, Ulanski P, Lugão AB. Radiation-synthesized protein-based drug carriers: Size-controlled BSA nanoparticles. International Journal of Biological Macromolecules. 2016;85:82-91. doi: 10.1016/j.ijbiomac.2015.12.074.

Country/Organization

BRAZIL

Type

Presentation

Year

2014

Description

"m. chinol, g. caviglioli, s. baldassari, e. russo, b. parodi, a. carollo, g. paganelli, “a new conjugate of human albumin and p-scn-bn-dota for radioguided occult lesion localization in breast cancer(roll)” j. nucl. med, 2014; 55(suppl. 1): 613 "

Country/Organization

Italy

Type

full paper

Year

2017

Description

Gibbens-Bandala BV, Ocampo-Garcia BE, Ferro-Flores G, Morales-Avila E, Ancira-Cortez A, Jaimes-Aguirre L. Multimeric System of RGD-Grafted PMMA-Nanoparticles as a Targeted Drug- Delivery System for Paclitaxel. Curr Pharm Des. 2017;23(23):3415-22. Epub 2017/04/14. doi: 10.2174/1381612823666170407143525. PubMed PMID: 28403791. https://www.ncbi.nlm.nih.gov/pubmed/28403791

Country/Organization

MEXICO

Type

full paper

Year

2016

Publication URL

https://www.sciencedirect.com/science/article/pii/S0141813016309473

Description

G.H.C. Varca, S. Kadlubowski, M. Wolszczak, A.B. Lugão, J.M. Rosiak, P. Ulanski, Synthesis of papain nanoparticles by electron beam irradiation – A pathway for controlled enzyme crosslinking, International Journal of Biological Macromolecules 92, 2016, 654–659, DOI:10.1016/j.ijbiomac.2016.07.070

Country/Organization

POLAND

Type

full paper

Year

2016

Description

Gamal-Eldeen AM, Moustafa D, El-Daly SM, El-Hussieny EA, Saleh S, Khoobchandani M, et al. Photothermal therapy mediated by gum Arabic-conjugated gold nanoparticles suppresses liver preneoplastic lesions in mice. Journal of photochemistry and photobiology B, Biology. 2016;163:47-56.

Country/Organization

USA

Type

full paper

Year

2017

Description

Sakr TM, Korany M, Katti KV. Selenium nanomaterials in biomedicine—An overview of new opportunities in nanomedicine of selenium. Journal of Drug Delivery Science and Technology. 2018;46:223-33. doi: 10.1016/j.jddst.2018.05.023.

Country/Organization

USA

Year

2015

Publication URL

http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3305/abstract;jsessionid=70C17DF…

Description

Esmail Mollarazi, Amir R. Jalilian, Fariba Johari-daha, Fatemeh Atyabi, Development of 153Sm-folatepolyethyleneimine-conjugated chitosan nanoparticles for targeted therapy, J. Label Compd. Radiopharm 2015, 58 327–335 Copyright © 2015 John Wiley & Sons, Ltd

Country/Organization

Iran

Type

GRADUATED STUDENT THESIS

Year

2016

Description

ALEJANDRA ANCIRA CORTÉZ, MSc Thesis “Preparación y caracterización denanopartículas de óxido de hierro funcionalizadas con Ácido fólico/Rodamina a través de una reacción de entrecruzamiento tipo Carbodiimida”

Country/Organization

MEXICO

Type

full paper

Year

2016

Description

Katti KV. Renaissance of nuclear medicine through green nanotechnology: functionalized radioactive gold nanoparticles in cancer therapy—my journey from chemistry to saving human lives. 2016;309(1):5-14. doi: 10.1007/s10967-016-4888-0. PubMed PMID: pub.1021561037.

Country/Organization

USA

Type

GRADUATED STUDENT THESIS

Year

2015

Description

EMILIA BUFFA, MSc Thesis “Synthesis and modification of nanogels for application in radiotherapy (Research activity carried out in POLAND-Lodz Erasmus exchange with POLAND-Lodz)”

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2017

Description

FOZIA IRUM, PhD Thesis “Studying Synthesis and Biodistribution of Gold-198 Nanoparticles by developing Carbohydrate Polymers as Reducing Agents”.

Country/Organization

PAKISTAN

Type

full paper

Year

2019

Description

Swidan MM, Khowessah OM, El-Motaleb MA, El-Bary AA, El-Kolaly MT, Sakr TM. Iron oxide nanoparticulate system as a cornerstone in the effective delivery of Tc-99 m radionuclide: a potential molecular imaging probe for tumor diagnosis. DARU Journal of Pharmaceutical Sciences. 2019:1-10.

Country/Organization

EGYPT

Type

PhD thesis

Year

2015

Description

Radiolabelled Chitosan Nanocarriers as promising agents for Imaging &Therapy of cancer " Esmaeel Molarazi , (2012-2015)

Country/Organization

Iran

Type

AWARDS

Year

2014

Description

Best Poster Presentation Award: WONGKRONGSAK, S., TANGTHONG, T., PASANPHAN, W. (2014, October 5-9). Electron beam induced water-soluble silk fibroin nanoparticles as a natural antioxidant and reducing agent for green synthesis of gold nanocolloid. Poster presentation (The best poster presentation award). The 11th Meeting of the Ionizing Radiation and Polymer Symposium (IRAP), Jeju, Korea.

Country/Organization

THAILAND

Type

full paper

Year

2016

Description

R.G. Queiroz, G.H.C. Varca, S. Kadlubowski, P. Ulanski, A.B. Lugão, Radiation-synthesized protein-based drug carriers: Size-controlled BSA nanoparticles, International Journal of Biological Macromolecules 85, 2016, 82–91, DOI:10.1016/j.ijbiomac.2015.12.074

Country/Organization

POLAND

Type

full paper

Year

2017

Description

Jaimes-Aguirre L, Morales-Avila E, Ocampo-García BE, Medina LA, López-Téllez G, Gibbens-Bandala BV, et al. Biodegradable poly (D, L-lactide-co-glycolide)/poly (L-?-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Materials Science and Engineering: C. 2017;76:743-51.

Country/Organization

MEXICO

Type

full paper

Year

2017

Description

Gamal-Eldeen AM, Moustafa D, El-Daly SM, Abo-Zeid MAM, Saleh S, Khoobchandani M, Katti KV. Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice. Biomedicine & Pharmacotherapy. 2017;89:1045-54. doi: https://doi.org/10.1016/j.biopha.2017.03.006.

Country/Organization

USA

Type

full paper

Year

2016

Description

Varca GHC, Queiroz RG, Lugão AB. Irradiation as an alternative route for protein crosslinking: Cosolvent free BSA nanoparticles. Radiation Physics and Chemistry. 2016;124:111-5. doi: 10.1016/j.radphyschem.2016.01.021.

Country/Organization

BRAZIL

Type

GRADUATED STUDENT THESIS

Year

2017

Description

LORENA ANNA DITTA, MSc Thesis “Doctorate in Innovation Technology” – XXX cycle. PhD Thesis: Ionizing radiation synthesis of multifunctional nanogels for biomedical applications”.

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2016

Description

THITIRAT RATTANAWONGWIBOON, PhD Thesis “Chemical and radiation induced synthesis of functional biopolymer-based nanoparticles for healthcare and medical applications”

Country/Organization

THAILAND

Type

GRADUATED STUDENT THESIS

Year

2019

Description

ERMINIA MUSCOLINO, MSc Thesis “Sintesi di nanogeli funzionalizzati con cisteina per l’incorporazione di radionuclidi di interesse terapeutico e diagnostico”

Country/Organization

ITALY

Type

full paper

Year

2016

Description

Mendoza-Nava H, Ferro-Flores G, Ramírez FdM, Ocampo-García B, Santos-Cuevas C, Aranda-Lara L, et al. 177Lu-Dendrimer Conjugated to Folate and Bombesin with Gold Nanoparticles in the Dendritic Cavity: A Potential Theranostic Radiopharmaceutical. Journal of Nanomaterials. 2016,Volume 2016, Article ID 1039258, doi.org/10.1155/2016/1039258.

Country/Organization

MEXICO

Type

full paper

Year

2016

Description

Adamo G, Grimaldi N, Campora S, Bulone D, Bondì ML, Al-Sheikhly M, et al. Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery. Molecules (Basel, Switzerland). 2016;21(11):1594. doi: 10.3390/molecules21111594.

Country/Organization

ITALY

Type

PATENTS

Description

Inventors: E. Morales-Avila, B. Ocampo-García, G. Ferro-Flores, B. Gibbens-Bandala, M.Trujillo-Nolasco Title:177Lu-DOTA-HA-PLGA(MTX) como un nuevo nanoradiofármaco para terapia dual de procesos inflamatorios que sobreexpresan receptores CD44. Patent number: MX/a/2018/006934

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2017

Description

MACARENA SIRI, PhD Thesis “Estudio de Nanopartículas Proteicas y su posible aplicación como vectores de drogas antitumorales”

Country/Organization

ARGENTINA

Type

GRADUATED STUDENT THESIS

Year

2019

Description

MOHAMED MANSOUR AHMED SWIDAN, PhD Thesis “Development and biologicalevaluation of a novel delivery system for radiopharmaceuticals”

Country/Organization

EGYPT

Type

full paper

Year

2016

Description

29. Saeed Shanehsazzadeh, Cordula Grüttner, Hassan Yousefnia, Afsaneh Lahooti, Amir Gholami, Sahar Nosrati, Samaneh Zolghadri, Sayyed Hossein Mousavie Anijdan, Alireza Lotfabadi, Behrang Shiri Varnamkhasti, Fariba Johari Daha, Amir Reza Jalilian. Development of 177Lu-DTPA-SPIO conjugates for potential use as adual contrast SPECT/MRI imaging agent. Radiochim. Acta 2016;104:337–344.

Country/Organization

Iran

Type

full paper

Year

2014

Publication URL

https://www.sciencedirect.com/science/article/pii/S0969806X14001364

Description

S. Kadlubowski, Radiation-induced synthesis of nanogels based on poly(N-vinyl-2-pyrrolidone)—A review, Radiation Physics and Chemistry, 102, 2014, 29-39, https://doi.org/10.1016/j.radphyschem.2014.04.016

Country/Organization

POLAND

Type

full paper

Year

2016

Description

14. Yousef Fazaeli, Shahzad Feizi, Amir R Jalilian, Ali Hejrani. Grafting of [64Cu]-TPPF20 Porphyrin Complex on Functionalized Nano-porous MCM-41 Silica as a Potential Cancer Imaging Agent, Applied Radiat Isotopes, 2016 ,112:13-9.

Country/Organization

Iran

Type

presentation

Year

2015

Description

"Radiosynthesis and Quality Control of Nanosized resveratrol-Au-198" T. M. Sakr, K.K. Katti, L. Watkinson, T. Carmack, C. J. Smith, C. Cutler, K. V. Katti. Journal of Labelled Compound and Radiopharmaceuticals, (ISRS 2015 Poster), 58, S403 (2015).

Country/Organization

Egypt

Type

PATENTS

Description

Inventors: Kattesh K. Katti, Raghuraman Kannan, Kavita K. Katti, Nripen Chanda, Ravi Shukla. Title: Soy or lentil stabilized gold nanoparticles and method for making same. Patent number: 8586096

Country/Organization

USA

Type

full paper

Year

2018

Description

Santos JJ, Leal J, Dias LAP, Toma SH, Corio P, Genezini FA, et al. Bovine Serum Albumin Conjugated Gold-198 Nanoparticles as Model To Evaluate Damage Caused by Ionizing Radiation to Biomolecules. ACS Applied Nano Materials. 2018;1(9):5062-70. doi: 10.1021/acsanm.8b01174.

Country/Organization

USA

Type

GRADUATED STUDENT THESIS

Year

2018

Description

BIONDO MARTINA, BSc Degree Thesis “Sistemi per il rilascio controllato di farmaci prodotti da polisaccaridi di origine marina”.

Country/Organization

ITALY

Type

full paper

Year

2014

Description

Chanda N, Upendran A, Boote EJ, Zambre A, Axiak S, Selting K, et al. Gold nanoparticle based X-ray contrast agent for tumor imaging in mice and dog: a potential nanoplatform for computer tomography theranostics. Journal of biomedical nanotechnology. 2014;10(3):383-92.

Country/Organization

USA

Type

full paper

Year

2015

Description

Achilli E, Casajus G, Siri M, Flores CY, Kadlubowski S, Alonso SDV, et al. Preparation of protein nanoparticle by dynamic aggregation and ionizing-induced crosslinking. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2015;486:161-71. doi: 10.1016/j.colsurfa.2015.09.047.

Country/Organization

Argentina

Type

GRADUATED STUDENT THESIS

Year

2017

Description

WINCZEWSKI JEDRZEJ, B.Sc Thesis “Synthesis of gold nanoparticles stabilized with a-lipoic acid”

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2019

Description

BRENDA VIANEY GIBBENS BANDALA, PhD Thesis “Preparación, caracterización y evaluación in vitro e in vivo de dos radiofármacos terapéuticos de liberación controlada basados en nanosistemas poliméricos”

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2016

Description

VALERIA D’ANGELO, MSc Thesis “Sintesi e modifica di nanogels per applicazioni radiofarmaceutiche”

Country/Organization

ITALY

Type

PATENTS

Description

Inventors: Katti, K. V.; Katti, K. K.; Lugão, A. B.; Varca, G. H. C.; Marques, F. L. N.; Ferreira, A.H. Title: Imaging agent from SPECT-probe-nanoparticle conjugates. Patent number: USPTO No 0800528.0143

Country/Organization

BRAZIL

Type

full paper

Year

2015

Description

R. Czechowska-Biskup, B. Rokita, P. Ulanski, J.M. Rosiak, Preparation of gold nanoparticles stabilized by chitosan using irradiation and sonication methods, Progress on Chemistry and Application of Chitin and its Derivatives, 20, 2015, 18-33, DOI:10.15259/PCACD.20.02. http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.psjd-97a4273e-07ec-411d-9860-16acf006f6a3

Country/Organization

POLAND

Type

Research paper

Year

2015

Publication URL

http://www.journals.elsevier.com/colloids-and-surfaces-a-physicochemical-and-eng…

Description

E. Achilli, G. Casajus, M. Siri, C. Flores, S. Kadlubowski, S.del V. Alonso, Mariano Grasselli. Preparation of protein nanoparticle by dynamic aggregation and ionizing induced crosslinking, Colloids and Surfaces A: Physicochemical and Engineering Aspects. (2015). 10.1016/j.colsurfa.2015.09.047

Country/Organization

Argentina

Type

GRADUATED STUDENT THESIS

Year

2016

Description

CHIARA CARBONE, MSc Thesis “Synthesis and modification of nanogels for biomedical applications (Research activity carried out in POLAND-Lodz)”

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2019

Description

GUSTAVO H. C. VARCA, PhD Thesis “Development of a nanostructured hydrogel based on polyvinylpyrrolidone containing papain complexed cyclodextrin”

Country/Organization

BRAZIL

Type

GRADUATED STUDENT THESIS

Year

2019

Description

MAYDELID TRUJILLO NOLASCO, PhD Thesis “Síntesis y evaluación de nanosistemas de liberación controlada basados en dendrimeros dirigidos al receptor de quimiocina-4”.

Country/Organization

MEXICO

Type

Presentation

Year

2015

Description

Ocampo-García B.E., Ferro-Flores G., Orocio- Ramírez F. de M., Santos-Cuevas C.L., Azorín-Vega E., Isaac-Olivé K. Two Novel Nanosized Radiolabeled Analogues of Somatostatin for Neuroendocrine Tumor Imaging, 21th International Symposium on Radiopharmaceutical Science, University of Missouri, Missouri, USA. May 26-31, 2015

Country/Organization

Mexico

Type

full paper

Year

2016

Description

Varca GHC, Kadlubowski S, Wolszczak M, Lugão AB, Rosiak JM, Ulanski P. Synthesis of papain nanoparticles by electron beam irradiation: A pathway for controlled enzyme crosslinking. International Journal of Biological Macromolecules. 2016;92:654-9. doi: 10.1016/j.ijbiomac.2016.07.070.

Country/Organization

BRAZIL

Type

GRADUATED STUDENT THESIS

Year

2019

Description

ESTEFANIA ACHILLI “Diseño de nanopartículas proteicas con reconocimiento molecular mediante entrecruzamiento radioinducido”

Country/Organization

ARGENTINA

Type

full paper

Year

2019

Description

Ditta LA, Dahlgren B, Sabatino MA, Dispenza C, Jonsson M. The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels. European Polymer Journal. 2019;114:164-75. doi: 10.1016/j.eurpolymj.2019.02.020.

Country/Organization

ITALY

Type

GRADUATED STUDENT THESIS

Year

2019

Description

MATUSIAK MALGORZATA, Ph.D Thesis “Radiation synthesis of polymer nanogels and their potential application as a carrier of bioactive substances”

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2018

Description

ROSA MAYDELID TRUJILLO NOLASCO, MSc. Thesis “Preparación y caracterización de nanopartículas de ácido poli(láctico-co-glicólico) PLGA modificadas con ácido hialurónico y radiomarcadas con 177Lu para la liberación controlada de metotrexato”

Country/Organization

MEXICO

Type

full paper

Year

2018

Description

RATTANAWONGWIBOON, T., GHAFFARLOU, M., SUTEKIN, S.D., PASANPHAN, W., GUVEN, O., “Preparation of multifunctional poly(acrylic acid)-poly(ethylene oxide) nanogels from their interpolymer complexes by radiation-induced intramolecular crosslinking”, Colloid Polym. Sci., 296 (2018) 1599–1608.

Country/Organization

Thailand

Type

GRADUATED STUDENT THESIS

Year

2015

Description

ADAMSKI WIKTOR, BSc Thesis “Polymeric carriers of active substances for use in radiotherapy”

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2014

Description

ROSALBA MONSERRAT MIRANDA OLVERA, BSc. Thesis “Sistema multivalente para la terapia de linfomas no-Hodking basado en Anti CD-20 conjugado a nanopartículas de oro”.

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2015

Description

RAJESH KULKARNI, MSc Thesis “Gold Nanoparticles in Radiosensitization for Imaging and Therapy”

Country/Organization

USA

Type

AWARDS

Year

2016

Description

Best Poster Presentation Award: TANGTHONG, T., PASANPHAN, W, “DOTA-BBN peptide conjugated water-soluble chitosan nanoparticles for a green synthesis of gold nanoplatform as a potential targeting radiopharmaceuticals”, Pure and Applied Chemistry International Conference (PACCON2016), Thailand: One hundred year of advancement chemistry, Bangkok, Thailand.

Country/Organization

THAILAND

Type

full paper

Year

2017

Description

Dispenza C, Sabatino MA, Ajovalasit A, Ditta LA, Ragusa M, Purrello M, et al. Nanogel-antimiR-31 conjugates affect colon cancer cells behaviour. RSC Advances. 2017;7(82):52039-47. doi: 10.1039/C7RA09797B

Country/Organization

ITALY

Type

full paper

Year

2018

Description

Flores CY, Achilli E, Grasselli M. Radiation-induced preparation of core/shell gold/albumin nanoparticles. Radiation Physics and Chemistry. 2018;142:60-4. doi: 10.1016/j.radphyschem.2017.02.030.

Country/Organization

Argentina

Type

Research paper

Year

2015

Description

Albumin-based nanoparticle trehalose lyophilisation stress-down to preserve structure/function. M.Siri, M. Grasselli, S. del V. Alonso. Journal of Pharmaceutical and Biomedical Analysis. Submitted Feb. 22nd 2016. JPBA-D-16-00302. Accepted.

Country/Organization

Argentina

Type

GRADUATED STUDENT THESIS

Year

2015

Description

SORAYA WONGKRONGSAK, MSc Thesis "Electron beam induced-silk fibroin nanoparticles and their conjugation with DOTA-bombesin for green synthesis of gold nanoparticles”

Country/Organization

THAILAND

Type

GRADUATED STUDENT THESIS

Year

2018

Description

SELENIA BRUNCO, MSc Thesis “Sinetsi e caratterizzazione di nanogeli funzionalizzati per applicazioni biomediche”.

Country/Organization

ITALY

Type

full paper

Year

2017

Description

Jaimes-Aguirre, L., Morales-Avila, E., Ocampo-García, B. E., Medina, L. A., López-Téllez, G., Gibbens-Bandala, B. V., & Izquierdo-Sánchez, V. (2017). Biodegradable poly (D, L-lactide-co-glycolide)/poly (L-?-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Materials Science and Engineering: C, 76, 743-751.

Country/Organization

MEXICO

Type

full paper

Year

2016

Description

Siri M, Grasselli M, Alonso S del V. Albumin-based nanoparticle trehalose lyophilisation stress-down to preserve structure/function and enhanced binding. Journal of pharmaceutical and biomedical analysis. 2016;126:66-74. Epub 2016/05/14. doi: 10.1016/j.jpba.2016.04.037. PubMed PMID: 27174378.

Country/Organization

Argentina

Type

full paper

Year

2017

Description

Morales-Avila, E., Ferro-Flores, G., Ocampo-García, B. E., López-Téllez, G., López-Ortega, J., Rogel-Ayala, D. G., & Sánchez-Padilla, D. (2017). Antibacterial efficacy of gold and silver nanoparticles functionalized with the ubiquicidin (29–41) antimicrobial peptide. Journal of Nanomaterials, 2017.

Country/Organization

MEXICO

Type

full paper

Year

2016

Publication URL

https://www.sciencedirect.com/science/article/pii/S0141813015302592

Description

R.G. Queiroz, G.H.C. Varca, S. Kadlubowski, P. Ulanski, A.B. Lugão, Radiation-synthesized protein-based drug carriers: Size-controlled BSA nanoparticles, International Journal of Biological Macromolecules 85, 2016, 82–91, DOI:10.1016/j.ijbiomac.2015.12.074

Country/Organization

POLAND

Type

GRADUATED STUDENT THESIS

Year

2018

Description

AMAL Y. AL-YASIRI PhD Thesis “Mangiferin functionalized Gold Nanoparticles in Imaging and Therapy”

Country/Organization

USA

Type

full paper

Year

2019

Description

Hajiramezanali M, Atyabi F, Mosayebnia M, Akhlaghi M, Geramifar P, Jalilian AR, Mazidi SM, Yousefnia H, Shahhosseini S, Beiki D. 68Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation. Int J Nanomedicine. 2019 Apr 10;14:2591-2605. doi: 10.2147/IJN.S195223. eCollection 2019.

Type

full paper

Year

2016

Description

Geraldes AN, da Silva AA, Leal J, Estrada-Villegas GM, Lincopan N, Katti KV, et al. Green nanotechnology from plant extracts: synthesis and characterization of gold nanoparticles. Advances in Nanoparticles. 2016;5(03):176.

Country/Organization

USA

Type

full paper

Year

2015

Description

Owen A, Dufès C, Moscatelli D, Mayes E, Lovell JF, Katti KV, et al. The application of nanotechnology in medicine: treatment and diagnostics. Nanomedicine. 2014;9(9):1291-4.

Country/Organization

USA

Type

GRADUATED STUDENT THESIS

Year

2015

Description

THEERANAN TANGTHONG, MSc Thesis "DOTA-BBN peptide conjugated water-soluble chitosan nanoparticles for a green synthesis of gold nanoplatform as a potential targeting radiopharmaceuticals”

Country/Organization

THAILAND

Type

full paper

Year

2015

Description

PASANPHAN, W., RATTANAWONGWIBOON, T., CHOOFONG, S., GUVEN, O., KATTI, K., “Irradiated chitosan nanoparticle as a water-based antioxidant and reducing agent for a green synthesis of gold nanoplatforms”, Radiat. Phys. Chem. 106 (2015) 360–370.

Country/Organization

Thailand

Type

GRADUATED STUDENT THESIS

Year

2018

Description

SZYMCZYK AGNIESZKA, B.Sc Thesis “Radiation synthesis of gold nanoparticles”

Country/Organization

POLAND

Type

full paper

Year

2018

Description

Sakr TM, Khowessah O, Motaleb M, El-Bary AA, El-Kolaly M, Swidan MM. I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery. European Journal of Pharmaceutical Sciences. 2018;122:239-45.

Country/Organization

EGYPT

Type

GRADUATED STUDENT THESIS

Year

2016

Description

LAURA JAIMES AGUIRRE, MSc Thesis “Obtención y caracterización de nanopartículas poliméricas de ácido poli(láctico-co-glicólico)/ácido poli(gama-glutámico) conjugadas con ácido fólico”

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2019

Description

THEERANAN TANGTHONG, PhD Thesis “DOTA-bombesin (DOTA-BBN) peptide conjugated biopolymers and gold nanoparticles synthesis as radiopharmaceutical nanocarrier and therapeutic agents”

Country/Organization

THAILAND

Type

GRADUATED STUDENT THESIS

Year

2019

Description

BASMA MOHAMED SAIED ESSA, PhD Thesis “Nano-sized Particles as New Radioisotopes Carriers for Medical Applications”

Country/Organization

EGYPT

Type

GRADUATED STUDENT THESIS

Description

WOJTCZAK EDYTA, MSc Thesis “Synthesis and properties of gold nanoparticles stabilized using hydrophilic polymers”

Country/Organization

POLAND

Type

full paper

Year

2014

Description

Ocampo García B.E., Miranda-Olvera R.M., Santos-Cuevas C.L., García-Becerra R., Azorín-Vega E.P., Ordaz-Rosado D., (2014). In vitro Decrease of the BCL-2 Protein Levels in Lymphoma Cells Induced by Gold Nanoparticles and Gold Nanoparticles-Anti-CD20, Nanoscience & Technology, 1(3): 1-6.

Country/Organization

MEXICO

Type

GRADUATED STUDENT THESIS

Year

2020 (PLANNED)

Description

RIZWANA ZAHOOR, PhD Thesis “Development of Multifunctional Radiolabelled Biomolecules for Cancer Diagnosis and Therapy”.

Country/Organization

PAKISTAN

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