Sub-cellular Imaging and Irradiation using Accelerator-based Techniques

Closed for proposals

Project Type

Coordinated Research Project

Project Code

F11024

CRP

2342

Approved Date

14 December 2022

Status

Active - Ongoing

Start Date

19 May 2023

Expected End Date

1 July 2028

Participating Countries

Australia
Brazil
China
Croatia
France
Germany
Italy
Japan
Portugal
Singapore
Spain
United Kingdom of Great Britain and Northern Ireland

Description

Accelerator techniques play an important role in the study of radiation effects in biological cells and provide important information on DNA damage and response that can potentially be translated to clinical trials and improved health outcomes for radiotherapy. With recent developments in high resolution ion beam and synchrotron-based X-ray microscopy imaging and sub-cellular targeting techniques, there is an opportunity to further develop, disseminate and promote the use of these techniques to better understand fundamental problems in radiobiology and cancer treatment.
The areas of investigation include the study of cell response to targeted sub cellular irradiation, uptake of nanoparticles for radio sensitization aided by high resolution imaging and irradiation, development of sample preparation protocols for live and fixed cell samples and the development of data acquisition systems, novel radiation detection systems based on quantum sensing, electronics and software tools for imaging and irradiation analysis at accelerator beamlines.

Objectives

To develop novel accelerator-based techniques for sub-cellular imaging and biological cell irradiation techniques in order to advance knowledge and capabilities in understanding how biological cells respond to radiation towards more efficient and tailored particle therapy.

Specific objectives

To compare the effectiveness of particle and photon-based irradiation techniques for cancer therapy through a detailed quantitative study of cell survival and other techniques.

To utilize advanced accelerator-based imaging techniques to enhance our understanding of fundamental processes that occur during and post irradiation under a wide variety of conditions such as beam, energy and dose.

To study the effectiveness and uptake of various types of nano particles used for radio-sensitization with high resolution imaging and irradiation using various particle and photon beams.

To develop new hardware and software for irradiation and imaging beamlines and to develop standard techniques that will be applied across partner laboratories.

To develop new and novel detector platforms for quantification of radiation and imaging for a variety of beam types and energies.

Contact the project officer

CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Image CAPTCHA

Stay in touch

Newsletter