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Sub-cellular Imaging and Irradiation using Accelerator-based Techniques
Closed for proposals
Project Type
Project Code
F11024CRP
2342Approved Date
Status
Start Date
Expected End Date
Participating Countries
Description
Accelerator techniques play an important role in the study of radiation effects in biological cells and provide important information on DNA damage and response that can potentially be translated to clinical trials and improved health outcomes for radiotherapy. With recent developments in high resolution ion beam and synchrotron-based X-ray microscopy imaging and sub-cellular targeting techniques, there is an opportunity to further develop, disseminate and promote the use of these techniques to better understand fundamental problems in radiobiology and cancer treatment.
The areas of investigation include the study of cell response to targeted sub cellular irradiation, uptake of nanoparticles for radio sensitization aided by high resolution imaging and irradiation, development of sample preparation protocols for live and fixed cell samples and the development of data acquisition systems, novel radiation detection systems based on quantum sensing, electronics and software tools for imaging and irradiation analysis at accelerator beamlines.
Objectives
To develop novel accelerator-based techniques for sub-cellular imaging and biological cell irradiation techniques in order to advance knowledge and capabilities in understanding how biological cells respond to radiation towards more efficient and tailored particle therapy.
Specific objectives
To compare the effectiveness of particle and photon-based irradiation techniques for cancer therapy through a detailed quantitative study of cell survival and other techniques.
To utilize advanced accelerator-based imaging techniques to enhance our understanding of fundamental processes that occur during and post irradiation under a wide variety of conditions such as beam, energy and dose.
To study the effectiveness and uptake of various types of nano particles used for radio-sensitization with high resolution imaging and irradiation using various particle and photon beams.
To develop new hardware and software for irradiation and imaging beamlines and to develop standard techniques that will be applied across partner laboratories.
To develop new and novel detector platforms for quantification of radiation and imaging for a variety of beam types and energies.