Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry

Closed for proposals

Project Type

Coordinated Research Project

Project Code

E21007

CRP

1528

Approved Date

30 October 2008

Status

4 - Closed

Start Date

11 June 2009

Expected End Date

11 June 2014

Completed Date

15 July 2015

Participating Countries

Bangladesh
Brazil
Croatia
Cuba
Egypt
Germany
South Africa
Thailand
United Kingdom of Great Britain and Northern Ireland
United States of America
Uruguay

Description

Nuclear Medicine instruments have the potential to provide quantitative information and its distribution with time. This information provides the basis for internal dosimetry and is needed to properly optimize the use of any radiopharmaceutical. Patient specific dosimetry is often a legal obligation when administering radiopharmaceuticals for therapy. There are, however, no harmonized protocols or guidelines for acquiring quantitative information from Nuclear Medicine instruments. Nor are there documents that address the possibilities and limitations of these instruments for quantitative information. This CRP aims at addressing this gap.

Objectives

The overall objective of this project is to assist Member States in accurately determining radionuclide distributions for diagnostic and therapeutic nuclear medicine.

Specific objectives

Assess the need for standardisation and harmonisation of quantitative nuclear medicine

Assess the need for training in the field of absolute quantitation and internal dosimetry

Determine the achievable accuracy of absolute activity quantitation for different nuclear medicine methodologies
in a range of sites with various levels of available resources

Develop and test quantitative imaging methods in nuclear medicine practice

Impact

1) The publication on Quantitative Nuclear Medicine Imaging (IAEA Human Health Reports No. 9) has been very popular in the Member States.
2) Through this CRP research networks were developed. The collaboration of the participants continues even after the end of the CRP.
3) The journal paper with the results of the Ba-133 intercomparison has received a lot of interest in the nuclear medicine medical physics community.

Relevance

The topic of the CRP is of continuous relevance with the objectives of the project 2.2.4.3, as it provides guidance to Member States to apply advanced and accurate dosimetry practices in therapeutic nuclear medicine.

CRP Publications

Type

J. Res. Natl Inst. Stand. Technol, 2013, 118: 359-74

Year

2013

Publication URL

http://www.nist.gov/manuscript-publication-search.cfm

Description

Calibration of Traceable Solid Mock 131I Phantoms Used in an International SPECT Image Quantification Comparison

Country/Organization

National Institute of Standards and Technology

Type

8th International Congress of the Croatian Society of Nuclear Medicine, Šibenik, May 9–12, 2014

Year

2014

Description

Activity Quantification of 133Ba Sources In Water Phantom

Country/Organization

Croatian Society of Nuclear Medicine

Type

Bangladesh Cancer Congress, Dhaka, Bangladesh, August 22-23, 2014

Year

2014

Description

Image Based Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study

Country/Organization

Oncology Club, Bangladesh

Type

8th International Congress of the Croatian Society of Nuclear Medicine, Šibenik, May 9–12, 2014

Year

2014

Description

Activity Quantification of 133Ba Sources In Water Phantom

Country/Organization

Croatian Society of Nuclear Medicine

Type

Bangladesh Journal of Nuclear Medicine Vol. 17, No. 1, January 2014, p. 80

Year

2014

Description

Ba-133 Phantom study to evaluate image based patient specific dosimetry in radionuclide therapy

Country/Organization

Society of Nuclear Medicine, Bangladesh

Type

Journal of Nuclear Medicine, 2013, 54.supplement 2: 2061-2061

Year

2013

Publication URL

http://jnm.snmjournals.org/content/54/supplement_2/2061

Description

Factors affecting repeatability of activity quantification in SPECT/CT

Country/Organization

Society of Nuclear Medicine

Type

Bangladesh Journal of Nuclear Medicine, Vol. 17, No. 2, July 2014, p. 134:137

Year

2014

Description

Quantification of Patient Specific Dosimetry in Radionuclide Therapy: A Phantom Study

Country/Organization

Society of Nuclear Medicine, Bangladesh

Type

28th EANM Annual Congress, Hamburg, October 10-14, 2015

Year

2015

Description

International Multicentre Evaluation of Absolute Quantification in Planar and SPECT Imaging

Country/Organization

European Association of Nuclear Medicine

Type

Phys Med Biol, 2015; 60:1325-1337

Year

2015

Publication URL

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437762/

Description

Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

Country/Organization

USA

Type

4th International Conference on Radiopharmaceutical Therapy, Ho Chi Minh City, Vietnam, November 28 – December 2, 2011

Year

2011

Description

Quantitative Study of the Different Protocols Analysis for Excess Radiation Absorbed Doses from Radioiodine Treatment of Hyperthyroidism in Bangladesh

Country/Organization

Bangladesh

Type

13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics, Singapore, December 12-14, 2013

Year

2013

Description

Development of Quantitative Nuclear Medicine Imaging for Patient Specific Dosimetry: IAEA Coordinated Research Project

Country/Organization

Asia-Oceania Congress of Medical Physics & South-East Asian Congress of Medical Physics

Type

XLII Congresso Brasileiro de Radiologia & XXVII Congresso Brasileiro de Medicina Nuclear, Curitiba, October 10-12, 2013

Year

2013

Description

Intercomparación de la cuantificación de imágenes en centros de Medicina Nuclear de América Latina. Resultados preliminaries

Country/Organization

Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, Brazil

Type

13th IRPA International Congress, Glasgow, May 14-18, 2012

Year

2012

Publication URL

http://www.irpa.net/members/TS7b.5.pdf

Description

Optimization of a routine method for bone marrow dose estimation in 177Lu-EDTMP therapy: Experience in Uruguay

Country/Organization

International Radiation Protection Association

Type

XIII Congreso de ALASBIMN, 28 September – 1 October, 2011

Year

2011

Description

Evaluación dosimétrica pre-terapéutica de 177Lu-DOTA-TATE en pacientes con tumores neuroendócrinos en Uruguay

Country/Organization

Asociación Latinoamericana de Sociedades de Biología y Medicina Nuclear

Type

Human Health Report

Year

In the editorial process

Description

Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods

Country/Organization

IAEA

Type

26th EANM Annual Congress, Lyon, October 19-23, 2013

Year

2013

Description

Effect of calibration source geometry on shape on absolute activity quantification in SPECT

Country/Organization

European Association of Nuclear Medicine

Type

2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)

Year

2013

Description

Accuracy and repeatability of quantitative 131-I SPECT: phantom design and benchmark results

Country/Organization

Society of Nuclear Medicine

Type

Bangladesh Journal of Nuclear Medicine, Vol. 15, No. 1, January 2012, p. 22-25

Year

2012

Description

Quantitative Study of Hyperthyroid Patient by Employing Different Protocols at the Institute of Nuclear Medicine and Ultrasound (INMU)

Country/Organization

Society of Nuclear Medicine, Bangladesh

Type

28th EANM Annual Congress, Hamburg, October 10-14, 2015

Year

2015

Description

International Multicentre Evaluation of Absolute Quantification in Planar and SPECT Imaging

Country/Organization

European Association of Nuclear Medicine and Molecular Imaging

Type

SNMMI Annual Meeting, St. Louis, USA, June 7-11, 2014

Year

2014

Publication URL

http://jnumedmtg.snmjournals.org/cgi/content/short/55/1_MeetingAbstracts/55

Description

International intercomparison of absolute quantification in nuclear medicine

Country/Organization

Society of Nuclear Medicine

Type

Bangladesh Journal of Nuclear Medicine, Vol. 16, No. 1, January 2013, p. 41-44

Year

2013

Description

Quantification of Thyroid Activity Using Conjugate View Method with Gamma Camera Images

Country/Organization

Society of Nuclear Medicine, Bangladesh

Type

Zeitschrift für Medizinische Physik

Year

2016

Publication URL

http://www.sciencedirect.com/science/article/pii/S0939388916300034

Description

International multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification

Country/Organization

German and Austrian Society of Medical Physics and the Swiss Society of Radiobiology and Medical Physics

Type

2014 Society of Nuclear Medicine Annual Meeting (St. Louis, USA)

Year

2014

Description

International intercomparison of absolute quantification in nuclear medicine

Country/Organization

Society of Nuclear Medicine

Type

Original Article

Year

2016

Publication URL

http://www.sciencedirect.com/science/article/pii/S0939388916300034

Description

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study

Country/Organization

Z. Med. Phys.

Type

Radiation protection dosimetry, 2010, 141.1: 50-55

Year

2010

Publication URL

https://rpd.oxfordjournals.org/content/141/1/50.full

Description

The determination of patient dose from 18F-FDG PET/CT examination

Country/Organization

Thailand

Type

ARCCNM/KSNM International Symposium, October 24-27, 2012, Seoul, Korea

Year

2012

Description

Quantification of Thyroid Uptake with Gamma Camera Images

Country/Organization

Asia Oceania Federation of Nuclear Medicine and Biology and Korean Society of Nuclear Medicine

Type

Journal of research of the National Institute of Standards and Technology

Year

2013

Publication URL

http://nvlpubs.nist.gov/nistpubs/jres/118/jres.118.017.pdf

Description

Calibration of Traceable Solid Mock 131I Phantoms Used in an International SPECT Image Quantification Comparison

Country/Organization

National Institute of Standards and Technology, Gaithersburg, USA

Type

2013 Society of Nuclear Medicine and Molecular Imaging Meeting (Vancouver, Canada)

Year

2013

Description

Stability of activity quantification in SPECT/CT

Country/Organization

Society of Nuclear Medicine

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