Nuclear Cardiology in Congestion Heart Failure

Closed for proposals

Project Type

Coordinated Research Project

Project Code

E13041

CRP

1980

Approved Date

13 September 2013

Status

4 - Closed

Start Date

13 September 2013

Expected End Date

30 November 2017

Completed Date

24 April 2018

Participating Countries

Algeria
Bolivia (Plurinational State of)
Brazil
Chile
Colombia
Cuba
India
Italy
Mexico
Pakistan
South Africa
Spain
United States of America
Viet Nam

Description

Heart failure is increasing worldwide at epidemic proportions, resulting in considerable disability, mortality and increase in healthcare costs. Gated Single Photon Emission Computed Tomography - Myocardial Perfusion Imaging (GSPECT MPI) is the most prominent imaging modality capable of providing information on the global and regional ventricular function, the presence of intraventricular synchronism and myocardial perfusion and viability with the same test. Since most heart failure patients will undergo a GSPECT MPI study as part of the work-up, and the technique is widely available, these patients can benefit from the simple additional phase analysis to measure left ventricular dyssynchrony as a mean to better assess those who will be submitted to cardiac resynchronization therapy (CRT).  CRT is an important new treatment for symptoms associated with congestive heart failure (CHF) caused by the weakening of the heart muscle (cardiomyopathy). Cardiomyopathy is most commonly caused by irreversible damage from coronary artery disease (CAD), but may also be the result of genetic factors, viral infections, or toxins (such as alcohol).  Many patients with cardiomyopathy and CHF also have an abnormality of the heart’s electrical system resulting in an uncoordinated (asynchronous) contraction pattern of the heart muscle. This further reduces the pumping ability of a weakened heart muscle. The idea behind CRT is simple: Restoration of the normal coordinated pumping action of the ventricles; this is accomplished through a unique type of cardiac pacemaker. Unfortunately 20%–40% of patients submitted to this expensive and with morbidity-associated therapy do not show response. It is of critical importance to better evaluate, properly select the candidates and guide this therapy.  The present protocol is proposed with the overall objective of improving the outcomes of heart failure patients by properly predicting response to CRT therapy and help guide the optimal placement of the left ventricular lead by using nuclear medicine techniques.

Objectives

To improve the clinical response of heart failure patients by properly predicting response to CRT therapy and helping guide the optimal placement of the LV lead by using nuclear medicine techniques

Specific objectives

To assess if gated MPI can predict the clinical response of patients submitted to CRT
To assess whether GSPECT MPI can guide the placement of the LV lead of the pacemaker for clinical results that lead to improved clinical response.

To assess if speckle-tracking echocardiogram can predict the clinical response of patients submitted to CRT
To assess whether speckle-tracking echo can guide the placement of the LV lead of the pacemaker for optimal clinical results that lead to improved clinical response.

CRP Publications

Type

Abstract

Year

2015

Description

Asociación entre la disincronía ventricular con parámetros de perfusión y función sistólica izquierdas en pacientes con insuficiencia cardiaca refractaria y bloqueo de rama izquierda. Teresa Massardo, Ángela Pino, Raimundo Morris, Javier Garate, Ivonne Aramburú, Solange Brugère, René Asenjo, Enrique Hiplán, Eduardo Swett, René Fernández, Luis Alarcón, Víctor Vera

Country/Organization

Chile

Type

Abstract

Year

2015

Description

Asociación entre marcadores sistémicos de disfunción endotelial y capacidad funcional en pacientes con insuficiencia cardíaca crónica. Teresa Massardo, Jaime Pereira, Ángela Pino, Macarena Palominos, Claudia Sáez, Alberto Leguina, Raimundo Morris, Ivonne Aramburu, Enrique Hiplan, M. Soledad Pérez.

Country/Organization

Chile

Type

Abstract

Year

2015

Description

Title: Avaliação Clínica e Cintilográfica de um Paciente Portador de Insuficiência Cardíaca com Bloqueio de Ramo Esquerdo Pré e Pós-Implante de Ressincronizador Cardíaco: um Caso de Sucesso. Christiane Cigagna Wiefels, Layanara Albino Batista, Annelise Passos Bispos Wanderley, Thais Helena Peixoto Nunes, Christiane Rodrigues Alves, Mario Luiz Ribeiro, Fernanda Baptista Ribeiro, Eduardo Nani Silva, Erivelton Alessandro Do Nascimento, Claudio Tinoco Mesquita

Country/Organization

Brazil

Type

Article

Year

2014

Description

Nuclear medicine in the management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA)

Country/Organization

IAEA

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