Radiation Therapy Planning of Non-Small Cell Lung Cancer based on PET/CT (Radiation Oncology component)

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Closed for proposals

Project Type

Coordinated Research Project

Project Code

E33038

CRP

2001

Approved Date

2013/11/13

Status

3 - Active - Ongoing

Start Date

2014/05/29

Expected End Date

2020/05/28

Participating Countries

Australia
Brazil
Estonia
India
Jordan
Netherlands
Pakistan
Poland
Turkey
United Kingdom of Great Britain and Northern Ireland
Uruguay
Viet Nam

Description

Non-small cell lung cancer (NSCLC) is considered in many countries as a leading cause of cancer related morbidity and mortality. While curative radiation therapy can be performed on patients who are surgically inoperable, local control and overall survival rates have historically been low, possibly due to inappropriate selection of patients and uncertainties in target definition.

Objectives

To improve the clinical outcomes of patients with NSCLC in Member States by the use of PET/CT in radiation therapy planning. This will be achieved by using a two phase design CRP. The first phase will measure baseline clinical outcomes and baseline target volume definition and then harmonise PET/CT based target volume definition. Phase two will measure clinical outcomes following the introduction of standardised PET/CT based radiotherapy treatment planning.Primary endpoint- 2-year overall survival.

Specific objectives

To assess the impact of the introduction of PET/CT based radiotherapy treatment planning on overall survival at 2 years.

Collection of baseline clinical outcome data of patients with Stage III NSCLC treated with non-PET/CT based 3D conformal radiotherapy / IMRT with a minimal biologically effective dose of 60 Gy.

To improve the quality and reproducibility of PET/CT based radiation therapy target volume definition in patients with Stage III NSCLC by means of a training intervention.

To improve the quality and reproducibility of PET/CT-based radiation therapy target volume definition in patients with NSCLC by means of a training intervention

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