New Ways of Producing Tc-99m and Tc-99m Generators (Beyond Fission and Cyclotron Methods)

Open for proposals

Project Type

Coordinated Research Project

Project Code

F22068

CRP

2140

Approved Date

07/04/2017

Status

3 - Active - Ongoing

Start Date

12/09/2017

Expected End Date

11/09/2020

Participating Countries

Brazil
Canada
China
Egypt
India
Indonesia
Iran (Islamic Republic of)
Japan
Morocco
Pakistan
Peru
Poland
Romania
South Africa
Ukraine
United States of America

Description

Technetium-99m radiopharmaceuticals are the major diagnostic tools in clinical practice of nuclear medicine worldwide covering 35 million procedures annually. The agents play important role in the diagnosis of cancer patients, cardiac patients and many other conditions. One of the main reasons is because Tc-99m is the decay product of longer-lived Molybdenum-99 (Mo-99) and can be readily available from a generator system (Mo-99/Tc-99m). The major part of Mo-99 for generator development is coming from fission route which is a well-established method. Due to recent Mo-99 crisis, many interesting achievements in the development of new methods of Tc-99m and Mo-99 production have taken place. This Coordinated Research Project (CRP) will identify new technical aspects of the production and quality control of Mo-99 and Tc-99m and T-99m generators with focus on photodynamic route through the reaction Mo-100(g,n)Mo-99 reaction, as well as generator development using high capacity adsorbents for Mo to be employed with low to medium specific activity Mo-99 for application and distribution among MS. The objectives for this CRP are to:Formulate guidelines to enhance and strengthen the expertise and capability of Member States in application of alternative routes for the production of Tc-99m and Mo-99, (in particular using linear accelerators), as well as the performance optimization of low/medium specific activity generators by improving the materials and accessory instruments.

Objectives

Formulate guidelines to enhance and strengthen the expertise and capability of Member States in developing the new production method of Mo-99 (based on photodynamic reaction) and also optimization of existing low-to-medium specific activity generators using high capacity absorbents for Mo in order to meet national needs.

Specific objectives

Application of new adsorbents with high capacity for Mo

Application of new optimized technical approaches to separate Tc-99m from Mo-99 such as electrochemical method as well as liquid extraction

Producing guidelines for the production of Mo-99 using linear accelerators through the Mo-100(g,n)Mo-99 reaction;

The optimization of available generators using auxiliary instruments

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