Instructive Surfaces and Scaffolds for Tissue Engineering Using Radiation Technology. (conducted jointly with F23030)

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Closed for proposals

Project Type

Coordinated Research Project

Project Code

E31007

CRP

2003

Approved Date

2013/09/13

Status

3 - Active - Ongoing

Start Date

2014/04/04

Expected End Date

2019/04/30

Participating Countries

Argentina
Brazil
Mexico
Russian Federation
Slovakia
United Kingdom of Great Britain and Northern Ireland
Uruguay

Description

This CRP will support interested institutions in the preparation and testing of instructive scaffolds and surfaces using radiation technology to create tissue grafts and help to decrease the need for human donors. It could also be considered as a forum for information, knowledge and technology exchange among participating institutions and could facilitate the formation of a network of specialists from the diverse disciplines involved. Radiation technologies can play an important role in facilitating and accelerating the development of tissue engineering by addressing some of the challenges and opportunities involved, such as preparation/optimization of instructive scaffolds and their sterilization. The CRP is jointly conducted by the Division of Physical and Chemical Sciences (NAPC) and the Division of Human Health (NAHU) within the IAEA Department of Nuclear Sciences and Applications. While NAPC will implement the part related to the development and testing of the instructive surfaces and scaffolds, NAHU will carry out the biomedical application part related to the end uses of the instructive surfaces and scaffolds.

Objectives

is to engineer instructive scaffolds and surfaces using radiation technology to create tissues from autologous and allogeneic human somatic cells to provide tissue grafts and decrease the need for human donors.

Specific objectives

To bring together researchers from different research directions with end-users

To investigate and optimize the preparation of instructive scaffolds and surfaces

To investigate the use of radiation sterilization of the new instructive scaffolds and decellularized matrices

To study cell-cell-scaffold-matrix-ECM interaction

To study the possibilities and effectiveness of combining biological and non-biological materials on regeneration/repair

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