Slide 5 of 49
Notes:
Tissues to be Sampled
Both pharmacokinetic data and the ability to collect the appropriate matrix help to decide which tissue to sample. In the latter case, on-farm samples are likely to be very different to those matrices selected at slaughter. For example, beat-agonists have been shown to accumulate in the retina. The eyeball may be collected at slaughter but could not be taken on-farm!.
The pharmacokinetics data for a particular antimicrobial drug, tilmicosin, demonstrates that liver contains higher residue levels over a longer period of time than other matrices. Liver is a suitable matrix in this example. Monitoring residues in fat is meaningless, since this drug is very unlikely to be detected in this matrix.
