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Hypoxanthine + H2O +O2 = xanthine + H2O2
xanthine + H2O +O2 = uric acid + H2O2
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Commercial products are usually derived from porcine liver, bovine milk, or Drosophila menganogaster |
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Optimum pH: 7.8-8.3 |
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Relative velocity: xanthine 1.0 and hypoxanthine 2.5 Michaelis constant: xanthine 2.35 x 10-5 and hypoxanthine 2.0 x 10-5 |
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Inhibitors: Several purines, pyrimidine and other heterocyclic compounds inhibit this enzyme. Excess substrate also inhibits this enzyme. |
Distribution in animal tissues
Some reports on the tissue distribution of xanthine oxidase in animals are listed below. One unit of XO activity is defined as 1 µmol uric acid produced per min at 37°C.
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